Molecular Life Sciences: An Encyclopedic Reference
Description: Molecular Life Sciences: An Encyclopedic Reference is a partnership between the American Society for Biochemistry and Molecular Biology and Springer. A major encyclopedic work, it will consist of multiple volumes focusing on understanding biological phenomena at the level of molecules and their interactions that govern life processes. Articles will include those with a focus on genes and genomes, and will contain areas such as DNA Replication, Repair and Recombination, Genes: Structure and Regulation, RNA Structure, Metabolism and Catalysis, Protein Synthesis, Post-translational Modification and Degradation, Transcription, Chromatin and Epigenetics, RNA Mediated Regulation and Non-Coding RNA, Genomics, Proteomics, Bioinformatics and Computational Approaches to Structure and Function. Also included will be articles on Protein Structure and Function featuring secondary, tertiary and quaternary structure, Protein Folding, Protein Dynamics, Enzyme Catalysis and Regulation, Metabolism and Bioenergetics, Ligand Binding and Protein Interactions, Mechanisms of Signal Transduction, Signal Transduction and Immunity, Molecular Basis of Cell and Developmental Biology, and Signal Transduction and Systems Biology. The molecular aspects of cell structure and function will be included with articles on Glycobiology and Extracellular Matrices, Lipids and Lipoproteins, Membrane Transport, Structure, Function and Biogenesis, and Metabolomics and Systems Biology; also included will be Unifying Concepts and Theory from Biology, Chemistry and Physics that are foundational for understanding the molecular life sciences together with articles on Teaching Perspectives and Assessment Tools. Each volume will include an overview describing the inter-relatedness of the themes of the section to facets of the molecular life sciences. Detailed overviews will be included along with a number of mini-reviews and shorter discussions of details and definitions, including appropriate experimental approaches.
Contents: Allostery and Quaternary Structure.- Analysis of Damaged DNA.- Artificial Chromosomes.- Artificial Endonucleases for Genome Editing.- Bacterial DNA Replicases.- Bacteriophage and Viral Cloning Vectors.- Base Intercalation.- Bioactivation of Carcinogens.- Bioinorganic Chemistry.- Blue/White Selection.- Characteristics of Enzymes and Cloning Vectors Used to Create Recombinant DNA.- Chemical Biology of DNA Replication.- Chemical Denaturation.- Chemical Reaction Kinetics: Mathematical Underpinnings.- Chromatin Remodeling during Homologous Recombination Repair in Saccharomyces Cerevisiae.- Cis-Regulation of Eukaryotic Transcription.- Classic Approaches to sequence determination.- Classical and Alternative End Joining.- Cloning Vector Compatibility.- Computational methods in epigenetic research.- Conjugative Transfer Systems and Classifying Plasmid Genomes.- Conservative Site-specific Recombination.- Control of Initiation in E.coli.- Co-Transcriptional mRNA Processing in Eukaryotes.- Crosslinking.- Cycling of the Lagging Strand Replicase During Okazaki Fragment Synthesis.- Depurination.- Differential Equations and Chemical Master Equation Models for Gene Regulatory Networks.- Direct Enzymatic Reversal of DNA Damage.- Division of Labor.- DNA Damage as a Therapeutic Strategy.- DNA Damage by Endogenous Chemicals.- DNA Methylation and Cancer.- DNA Polymerase III Structure.- DNA Repair.- DNA Repair Polymerases.- DNA Replication.- DNA Topology and Topoisomerases.- DnaA, DnaB, DnaC.- DnaX Complex Composition and Assembly Within Cells.- Double-strand Break Repair.- Effects of adducts on Tm.- Equilibria and Bifurcations in the Molecular Biosciences.- Eukaryotic DNA Replicases.- Evolution of Gene Regulatory Networks.- Evolution of Plant Genomes.- Exocyclic Adducts.- Experimental Assessment of Secondary Structure by Circular Dichroism.- Exploring Nuclear Lamin–Chromatin Interactions and Their Signalling Cascades.- Expression Assessment.- Fatty Acid Metabolism.- Forces Maintaining the Stability of Tertiary Structure.- Frequency of DNA Damage.- Gene Regulation.- Genes and Genomes: Structure.- Genomic Imprinting.- Genomic Imprinting in Mammals: Memories of Generations Past.- Genomic Sequence and Structural Diversity in Plants.- Genomic Signature Analysis to Predict Plasmid Host Range.- Golgi Apparatus.- Gyrase and Topoisomerase IV as Targets for Antibacterial Drugs.- HDAC Inhibitors Entinostat and Suberoylanilide Hydroxamic Acid (SAHA): The Ray of Hope for Cancer Therapy.- Helicase and Primase Interactions with Replisome Components and Accessory Factors.- Helicase Mechanism of Action.- Hereditary Breast and Ovarian Cancer and Poly(ADP-ribose) Polymerase Inhibition.- Homologous Recombination in Lesion Bypass.- Hydrolytic, Deamination, and Rearrangement Reactions of DNA Adducts.- Immunology and the Immune Response.- In Silico Approaches Towards Safe Targetting of Class I Histone Deacetylases.- Inflammation and Host Response to Infection.- Innate and Regulatory B cells